The river is slightly tannin colored but at a great flow for fishing. Look for black drake mayflies hatching throughout the river. When the hatch is on, rising fish can be found at almost all public access areas. ‌

Best places to fish for brown trout and redband trout are the fast water areas near Chiloquin High School, the narrows and near all the springs in Beatty. Boats can be launched at two locations above Beatty. ‌

There are a few warmwater fish in the Sprague. The dominate warmwater fish is yellow perch. A few largemouth bass are around but their population has declined. There are also small brown bullhead. The best place to fish for warmwater fish is above Saddle Mtn Pit Road Bridge to near Godowa Springs Road Bridge. Bait is allowed in this section.‌

Anglers can find several kinds of flow date here: Near Real Time Hydrographics Data.